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More Neanderthal DNA identified in present day humans


The high quality genome of a Neanderthal from Croatia in southern Europe has been sequenced at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. This Neanderthal is more closely related to the group of Neanderthals that mixed with the ancestors of present-day non-Africans than the previously sequenced Neanderthal from the Altai Mountains. This allowed the researchers to identify additional Neanderthal DNA in the genomes of present-day people.

More Neanderthal DNA identified in present-day humans
Entrance of the Vindija Cave in Croatia [Credit: © MPI f. Evolutionary Anthropology/J. Krause]
Researchers at the Max Planck Institute for Evolutionary Anthropology in Leipzig have sequenced to high-quality the genome of a female Neanderthal from a bone discovered in 1980 in Vindija Cave, Croatia. This is the second high-quality genome sequence of a Neanderthal to be published; in 2014 the same group sequenced the genome of an older Neanderthal from the Altai Mountains in Siberia.

By comparing the two Neanderthals the scientists could show that they were much more closely related to each other than any two humans are today. “Such a close relationship for individuals that lived thousands of kilometers apart and probably thousands of years apart shows that Neanderthals must have had a small population size” says Fabrizio Mafessoni, a researcher at the Max Planck Institute.

The team also compared the two Neanderthals to people living today to learn more about the Neanderthals who mixed with the ancestors of present-day non-Africans. “We see that the Croatian Neanderthal is more closely related to the Neanderthals that mixed with our ancestors than the older Neanderthal from Siberia”, explains Steffi Grote, who analyzed the genomes in Leipzig. The research showed that between 1.8 and 2.6 percent of the genomes of people outside of Africa originates from this admixture.

Using the new Neanderthal genome the researchers were able to identify additional Neanderthal variants that entered the genomes of modern humans by interbreeding. “The Croatian Neanderthal genome helps us to identify more of the Neanderthal DNA in humans living today” says Kay Prüfer who together with Svante Pääbo led the analysis of the new Neanderthal genome. “Some of these variants seem to provide protection from certain diseases while other variants are associated with increased susceptibility to some diseases.”

The findings are published in the journal Science.

Source: Max Planck Institute for Evolutionary Anthropology [October 05, 2017]
TANN

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