Archaeology / Cultural Heritage

[Archaeology] [twocolumns]

Anthropology / Human Evolution

[Anthropology] [twocolumns]

Palaeontology / Earth Sciences

[Palaeontology] [twocolumns]

Evolution / Genetics

[Evolution][twocolumns]

Fish study shows important genome interactions in animal cells


In a new study, researchers at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science examined how the interaction of two genomes in animal cells—the mitochondrial and nuclear genomes—interact to affect adaptation of the Atlantic killifish to different temperatures. They showed that although these genomes are separate physical entities, the mitochondrial genome affects the evolution of the nuclear genome, the genetic material responsible for variations in most traits such as hair color and height.

Fish study shows important genome interactions in animal cells
A salt water marsh, where F. heteroclitus naturally occur. Individuals used in the study were collected in marshes 
in Mantoloking, NJ. Inset: a male F. heteroclitus [Credit: Douglas Crawford]
Interactions between these two genomes, which affect everything from health and physiology to fitness, have important consequences for human health and medical interventions such as mitochondrial replacement therapy in embryos.

All animal cells are made up of two genomes, the nuclear genome with 10,000s of protein coding genes and the mitochondrial genome with 13 protein-encoding genes. All 13 genes from the mitochondrial genome interact with approximately 76 nuclear genes in a single metabolic pathway—called the oxidative phosphorylation pathway—that produces nearly all the metabolic energy needed for animal cells. This study found that the interaction between these genomes and the implications on energy production is strong enough that the mitochondrial genome can alter which version of a gene is present in the nuclear genome.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial-nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry. Among individuals with two divergent mitochondrial haplotypes (mt-haplotypes), the genome-wide analyses revealed significant differences in nuclear allele frequencies.

"Our results suggest that metabolic fitness is not simply a function of the mitochondria but instead is reliant on mitochondrial-nuclear interactions and therefore important for our understanding of physiology, human health and evolution," said Doug Crawford, professor of marine biology and ecology at the UM Rosenstiel School.

The study is published in the journal PLoS Genetics.

Source: University of Miami [April 04, 2017]
TANN

Post A Comment
  • Blogger Comment using Blogger
  • Facebook Comment using Facebook
  • Disqus Comment using Disqus

No comments :


Exhibitions / Travel

[Exhibitions] [bsummary]

Natural Heritage / Environment / Wildlife

[Natural Heritage] [list]

Astronomy / Astrobiology / Space Exploration

[Universe] [list]