Shedding light on the evolution of whale vision
|A model of the killer whale rhodopsin protein illustrating its evolution in response|
to underwater light [Credit: Sarah Dungan/University of Toronto]
Sarah Dungan, PhD candidate and lead author of the study elaborates: "Rhodopsin is a light-sensitive protein in the rod cells of your eyes that allows you to see even in dark conditions. Whales are particularly relianton rhodopsin because light fades very quickly with depth underwater. But the majority of light in the ocean is also blue, so if you're a deep diver like a sperm whale, having rhodopsin more sensitive in the blue part of the spectrum allows your eyes to make the most use of the scarce light hundreds of meters below the surface. This could mean the difference between catching your prey or going hungry."
These functional aspects of protein evolution are often overlooked when selection signatures in genes or genomes are over-emphasized. "Bioinformatics and evolutionary statistics are hot areas of research now," according to Dungan, "but to say anything about adaptation you need to also show how genetic changes may be of benefit to the organism, and that often requires an interdisciplinary approach."
"Visual proteins like rhodopsin are ideal for this kind of research because their functional response to light can be directly measured in vitro," adds Dr. Belinda Chang, an expert in the biology of vision and visual protein biochemistry, and leader of the lab behind the study. "The computational methods tell us where to focus our efforts. Which parts of the gene's DNA sequence has natural selection been changing? Which structural areas of the rhodopsin protein do these correspond to? But the mutation experiments show us what those evolutionary changes actually do to the protein's function – that they shift rhodopsin's sensitivity to different parts of the light spectrum."
The study's results, published in Molecular Biology and Evolution, show computational and experimental evidence of natural selection in whale rhodopsin for vision in underwater environments, illuminating one facet of how these remarkable creatures have adapted to life in the sea.
Source: University of Toronto [February 20, 2016]